[11C]NOP-1A and Cocaine Use Disorders

• Status: Completed
• Trial end date: 2019-02-20
• Target enrollment: 0
• Participant gender: All

Summary

The goal of this study is to compared [C-11]NOP-1A binding in recently abstinent cocaine use disorders and controls.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Pittsburgh
• Collaborator: National Institute on Drug Abuse (NIDA)
• Treatments: Cocaine

Criteria

[A]Cocaine use disorders

Inclusion criteria:

1. Males or Females 18-50

2. Fulfill DSM-5 Diagnosis for Cocaine use disorder

3. Medically Healthy

Major exclusion criteria:

1. Pregnancy or lactation

2. Comorbid medical, psychiatric, drug use disorders (other than cocaine, tobacco use, and recreational marijuana/alcohol use)

3. Metal implants or paramagnetic objects contained within the body which may interfere with the MRI scan

4. Currently employed as radiation worker; or participation in radioactive drug research protocols within the previous year

5. Currently on any psychotropic medications that can influence nociceptin transmission in the brain (e.g., morphine, suboxone, SSRIs, etc.)

[B] Healthy controls

Inclusion criteria:

1. Males or Females 18-50

2. Absence of present or past psychiatric conditions (including alcohol or drug use disorders)

3. A negative urine drug screen

4. Medically Healthy

Major exclusion criteria

1. Pregnancy or lactation

2. Medical, psychiatric or drug & alcohol use disorders

3. Metal implants or paramagnetic objects contained within the body which may interfere with the MRI scan

4. Currently employed as radiation worker; or participation in radioactive drug research protocols within the previous year

5. Currently on any psychotropic medications that can influence nociceptin transmission in the brain

6. Family history of a psychotic disorder, manic episode, drug use disorders in first-degree relatives.